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Related Experiment Video

Updated: Jun 26, 2026

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

NIH Chronic Graft-Versus-Host Disease Consensus Conference 2025 Update.

Stephanie J Lee¹, Kirsten M Williams², Stefanie Sarantopoulos³

¹Clinical Research Division and Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.

Transplantation and Cellular Therapy

|May 23, 2025

Summary

Progress on chronic graft-versus-host disease (GVHD) research is modest. A 2020 NIH project set goals for GVHD clinical trials, with an interim review in 2024 showing some studies are advancing the field.

Keywords:

Allogeneic transplantation BIOMARKERS CONFERENCE Chronic GvHD TREATMENT

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Last Updated: Jun 26, 2026

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Published on: February 11, 2019

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR

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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

Area of Science:

Hematology
Immunology
Oncology

Background:

The 2020 NIH Consensus Development Project aimed to address knowledge gaps in chronic graft-versus-host disease (GVHD).
Chronic GVHD remains a significant challenge post-hematopoietic stem cell transplantation.
Actionable recommendations were established to advance the understanding, prevention, and treatment of chronic GVHD.

Purpose of the Study:

To review progress made on the 2020 recommendations for chronic GVHD clinical trials.
To assess the current trajectory of the field towards achieving established goals.
To redefine the research agenda for future chronic GVHD studies.

Main Methods:

Convening working groups to review prior recommendations.
Evaluating progress against established goals for chronic GVHD research.
Assessing the impact of new data and identifying areas needing further investigation.

Main Results:

Modest progress has been observed across most research initiatives.
Several ongoing studies are directly addressing key recommendations from the 2020 project.
The working groups' reports provide a summary of advancements and future directions.

Conclusions:

The field is making slow but steady progress in chronic GVHD research.
Future research should focus on key recommendations to accelerate advancements.
Anticipation is high for results from ongoing studies addressing critical aspects of chronic GVHD.