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Prognostic value of hemoglobin to serum creatinine ratio in ST-elevation myocardial infarction: a secondary analysis

Weibiao Ji1, Yangbo Chen1, Haoyue Zhou1

  • 1Department of Cardiology, Jieyang People's Hospital, Jieyang, 522000, Guangdong, China.

BMC Cardiovascular Disorders
|May 23, 2025
PubMed

Insights

A lower hemoglobin to serum creatinine (HB/SCr) ratio predicts major adverse cardiovascular events (MACE) in ST-elevation myocardial infarction (STEMI) patients. This ratio may help identify high-risk STEMI individuals early.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Outcomes

Background:

  • The prognostic significance of the hemoglobin to serum creatinine (HB/SCr) ratio in ST-elevation myocardial infarction (STEMI) is not well-established.
  • Predicting long-term clinical outcomes in STEMI patients is crucial for risk stratification.

Purpose of the Study:

  • To investigate the predictive value of the HB/SCr ratio for major adverse cardiovascular events (MACE) in STEMI patients.
  • To assess the HB/SCr ratio as a potential biomarker for long-term MACE in STEMI.

Main Methods:

  • Prospective cohort study of 460 STEMI patients undergoing primary percutaneous coronary intervention.
  • Cox proportional hazards models and receiver operating characteristic curve analysis were used to evaluate the association between HB/SCr ratio and MACE over 30 months.

Main Results:

  • A lower HB/SCr ratio was a significant independent predictor of MACE in STEMI patients.
  • The HB/SCr ratio showed an inverse association with MACE across various subgroups, including older patients and those with hypertension.
  • The area under the curve for predicting MACE using the HB/SCr ratio was 0.611.

Conclusions:

  • The baseline HB/SCr ratio is inversely associated with long-term MACE in STEMI patients.
  • The HB/SCr ratio may serve as a valuable early biomarker for identifying high-risk STEMI patients.
Abstract

Keywords:
Cohort studyCreatinineHB/SCr ratioPrognosticST-elevation myocardial infarction

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