Related Experiment Video
Updated: Sep 20, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
Persistence of a High Seroconversion Rate 3.2 ± 0.13 Years After Last COVID-19 Vaccination in Heart Transplant
Robin Arcani1, Pierre Ambrosi2
1Laboratory of Therapeutics and the Aix-Marseille Universite, Marseille, France.
Abstract:
We previously reported a high level of seroconversion 1 year after COVID-19 vaccination in heart transplant recipients when vaccination was performed several years after transplantation. The aim of this study was to measure the seroconversion rate late after vaccination, in the absence of a new vaccine injection. We included 37 patients vaccinated in 2021. We measured immunoglobulin response using TrimericS Diasorin assay at the last visit between October 2024 and February 2025. We found a seroconversion rate of 95%, 3.2 ± 0.13 years after last COVID-19 vaccination in the absence of new vaccine injection. Most of these patients (73%) had a proven COVID-19 infection since vaccination. Interestingly, none of these patients had a severe form of COVID-19. Thus, vaccination, followed by minor COVID-19 infections, effectively prevented severe forms.
Related Concept Videos
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Endocarditis III: Medical Management
Heart Failure III: Clinical Manifestations
Endocarditis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Kidney Transplant I: Introduction

