Related Experiment Video
Updated: Sep 20, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Stereocontrol in Conformationally Stable C(sp2)─C(sp3) Atropisomers
Antoine Domain1, Guishun Bai2, Juan-Carlos Castillo3
1Aix Marseille Univ, CNRS, Centrale Med, iSm2, Marseille, France.
None:
We report a two-step sequence for the enantioselective construction of a rare family of stable C(sp2)─C(sp3) atropisomers featuring two additional stereogenic centers. The process begins with an organocatalyzed dihydrobenzofurannulation that establishes and controls the stereochemistry of two carbon centers, followed by a highly diastereoselective functionalization that significantly enhances the barrier to diastereomerization of the C(sp2)─C(sp3) bond, effectively locking and stabilizing its configuration.
More Related Videos
Related Concept Videos
Stereoisomerism of Cyclic Compounds
Stereoisomers
Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Molecules with Multiple Chiral Centers
Isomerism
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement

