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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
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Post-pulmonary tuberculosis lung function: a systematic review and meta-analysis.
Sharina Ratnakumar1, Sally E Hayward2, Emma K Denneny3
1UCL Respiratory, University College London, London, UK; St George's School of Health and Medical Sciences, City St George's University of London, London, UK.
The Lancet. Global Health
|May 24, 2025
Summary
Pulmonary tuberculosis survivors experience significantly reduced lung function, particularly forced expiratory volume in 1 second (FEV1), indicating persistent respiratory impairment. This systematic review highlights the long-term impact of tuberculosis on lung health.
Area of Science:
- Pulmonary Medicine
- Respiratory Physiology
Background:
- Post-tuberculosis lung disease is a significant health concern.
- Objective data on functional impairment in tuberculosis survivors are limited.
Purpose of the Study:
- To systematically review and meta-analyze lung function impairment after pulmonary tuberculosis.
- To examine differences in ventilatory defects in tuberculosis survivors.
Main Methods:
- Systematic search of Embase, MEDLINE, and CINAHL databases (2000-2024).
- Inclusion of studies comparing lung function tests in pulmonary tuberculosis survivors versus healthy controls.
- Extraction of spirometric data including FEV1, FVC, and their ratios; use of random effects models for meta-analysis.
Main Results:
- Analysis of 19 studies involving 7447 tuberculosis survivors.
- Significant negative impact of prior pulmonary tuberculosis on absolute FEV1, FVC, and FEV1/FVC ratio.
- Pooled standardized mean differences indicated reduced FEV1% and FVC% in survivors compared to controls.
Conclusions:
- Individuals recovering from pulmonary tuberculosis exhibit significantly decreased lung function.
- FEV1 is more affected than FVC, suggesting a mixed obstructive and restrictive pattern with predominant airflow obstruction.
- The findings underscore the chronic respiratory consequences of pulmonary tuberculosis.
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