Role of Adjuvant Therapy in Current Perioperative Immunotherapy-based Trials in Bladder Cancer: A Justified Standard
1AdventHealth Cancer Institute and the University of Central Florida, Orlando, Florida, USA.
European Urology Focus
|May 24, 2025
Abstract:
None of the ongoing phase 3 trials are evaluating the impact of the adjuvant component of perioperative PD1/PDL1 inhibition combined with neoadjuvant chemotherapy for muscle-invasive bladder cancer. Biomarkers of benefit are not validated. Hence, omission of the adjuvant component cannot be supported. Prospective investigation is required to evaluate this question.
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