Jove
Visualize
Contact Us

Related Concept Videos

Glycosaminoglycans01:23

Glycosaminoglycans

8.0K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is It Really Less Painful to Undergo Total Hip Arthroplasty than Total Knee Arthroplasty?

The Journal of arthroplasty·2026
Same author

Increasing adverse event reports coincide with declining Medicare billings for interspinous devices.

North American Spine Society journal·2026
Same author

Modulating Micrococcal Nuclease-Triggered Antibiotic Releases for One-Stage Revisions of <i>Staphylococcus aureus</i>-Infected Prostheses.

ACS infectious diseases·2026
Same author

Pulling the Trigger Sooner: Patients Pursue Subsequent Contralateral Total Joint Arthroplasty With Lower Preoperative Pain.

The Journal of the American Academy of Orthopaedic Surgeons·2026
Same author

Rat Spine Fusion Models for Preclinical Research: Opportunities and Challenges.

ACS biomaterials science & engineering·2025
Same author

Patient Satisfaction Following Total Hip Arthroplasty May Be As High As 95.

The Journal of the American Academy of Orthopaedic Surgeons·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 17, 2026

Interlinked Macroporous 3D Scaffolds from Microgel Rods
07:32

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

2.8K

Tuning Hyaluronic Acid Microstructures by Engineered Amphiphilicity: From Dynamically Cross-Linked Gels to

Shing-Yun Chang1, Aidan P McAnena1, Joshua Kim1

  • 1Department of Orthopedics & Physical Rehabilitation, Department of Biochemistry & Molecular Biotechnology, UMass Chan Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, United States.

ACS Applied Materials & Interfaces
|May 26, 2025
PubMed
Summary

Cholesterol-modified hyaluronic acid forms tunable gels and nanoparticles for regenerative medicine. These amphiphilic biopolymers effectively deliver drugs and promote bone healing.

Keywords:
amphiphilicitycholesterolhyaluronic acidmultilamellar nanoparticleviscoelastic hydrogel

More Related Videos

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
09:09

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Published on: February 27, 2016

10.7K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.2K

Related Experiment Videos

Last Updated: Apr 17, 2026

Interlinked Macroporous 3D Scaffolds from Microgel Rods
07:32

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

2.8K
Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
09:09

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Published on: February 27, 2016

10.7K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.2K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Amphiphilic biopolymers are crucial for regenerative medicine due to their ability to interact with diverse bioactive molecules.
  • Hyaluronic acid (HA) is a hydrophilic biopolymer with potential for self-assembly into microstructures.

Purpose of the Study:

  • To tune the amphiphilicity and microstructures of hyaluronic acid (HA) by integrating cholesterol.
  • To explore the potential of cholesteryl HA as a versatile building block for regenerative medicine applications.

Main Methods:

  • Stoichiometric integration of cholesterol into azide-functionalized HA via strain-promoted azide-alkyne cycloaddition (SPAAC).
  • Characterization of physical gels and multilamellar nanoparticles (NPs) formed by cholesteryl HA.
  • Assessment of NP encapsulation efficiency, drug protection, cellular internalization, and in vitro osteogenesis.

Main Results:

  • Cholesteryl HA forms physical gels at low cholesterol content, exhibiting enhanced and recoverable viscosity.
  • Dual-cross-linked gels were achieved by combining physical and chemical cross-linking.
  • At higher cholesterol content, cholesteryl HA self-assembles into multilamellar NPs with a layered core and hydrated outer layer.
  • Amphiphilic NPs efficiently encapsulated hydrophobic compounds and protected hydrophilic vitamin C.
  • Cholesteryl HA NPs demonstrated rapid internalization by stromal cells and robust in vitro osteogenesis when loaded with dexamethasone and vitamin C.

Conclusions:

  • Tailored amphiphilicity of cholesteryl HA allows for the creation of versatile macromolecular building blocks.
  • Cholesteryl HA can be engineered into viscoelastic gels, dual-cross-linked gels, or multilamellar NPs for diverse regenerative medicine applications.