Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jan 18, 2026

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Trends in 4D Printed Shape Memory Biomaterials for Tissue Engineering Applications.

Deepak Kumar¹, Rishabha Malviya¹, Sathvik Belagodu Sridhar²

¹Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India.

Current Pharmaceutical Design

|May 26, 2025

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

5D and 6D bio-printed cellulose for neural tissue regeneration: advancement in next generation precision therapy.

Journal of biomaterials science. Polymer edition·2026

Same author

Microbiota-Sensitive Nanocarriers for the Targeted Delivery of Therapeutic Agents into the Gut: Advanced Treatment Strategy for Inflammatory Bowel Disease.

Current pharmaceutical design·2026

Same author

Ribosome-targeted and Adjuvant Strategies to Combat Antibiotic Resistance.

Infectious disorders drug targets·2026

Same author

Significance of Paraptosis in Cancer Treatment and its Induction by Natural Molecules.

Current topics in medicinal chemistry·2026

Same author

Efficacy of Dual Glucagon and GLP-1 Agonists as New Treatments for Type II Diabetes.

Mini reviews in medicinal chemistry·2026

Same author

Nuclei-targeted Therapeutic Delivery: A Novel Concept for the Treatment of Cancer.

Mini reviews in medicinal chemistry·2025

Smart shape memory polymers (SMPs) in 4D printing create dynamic tissue scaffolds. These responsive biomaterials enhance tissue regeneration by mimicking natural tissue behavior, though clinical use faces challenges.

Area of Science:

Biomaterials Science
Tissue Engineering
4D Printing

Background:

Shape memory polymers (SMPs) and stimuli-sensitive materials are key to advanced 4D printing.
These materials enable the creation of dynamic and flexible tissue structures.
Their responsiveness to stimuli like pH, light, and temperature is crucial for tissue engineering.

Purpose of the Study:

To review the application of smart SMPs in 4D printing for tissue engineering.
To emphasize the response of these materials to diverse physical and chemical stimuli.
To explore the influence of smart SMPs on biological applications.

Main Methods:

A comprehensive literature review was conducted.
Data was compiled from electronic databases (Scopus, Google Scholar, PubMed, Science Direct).

Keywords:

4D printing clinical application.fabrication techniques regenerative medicine shape memory biomaterials smart materials tissue engineering

More Related Videos

Novel Process for 3D Printing Decellularized Matrices

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

4D Printed Bifurcated Stents with Kirigami-Inspired Structures

4D Printed Bifurcated Stents with Kirigami-Inspired Structures

Published on: July 25, 2019

Related Experiment Videos

Last Updated: Jan 18, 2026

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Novel Process for 3D Printing Decellularized Matrices

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

4D Printed Bifurcated Stents with Kirigami-Inspired Structures

4D Printed Bifurcated Stents with Kirigami-Inspired Structures

Published on: July 25, 2019

Studies from the last 10 years were preferably included.

Main Results:

Smart SMPs integrated with 4D printing offer significant potential for tissue engineering.
Responsive biomaterials allow for the design of dynamic scaffolds that mimic native tissue.
Enhanced tissue regeneration can be achieved by utilizing material responsiveness to physiological signals.

Conclusions:

4D-printed shape memory biomaterials can advance tissue engineering through adaptable scaffolds.
Challenges include material limitations and scaling up production for clinical implementation.
Further research is needed to overcome obstacles for successful clinical translation.