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A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment
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Improving annotation efficiency for fully labeling a breast mass segmentation dataset.

Vaibhav Sharma1, Alina Jade Barnett1, Julia Yang1

  • 1Duke University, Department of Computer Science, Durham, North Carolina, United States.

Journal of Medical Imaging (Bellingham, Wash.)
|May 26, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces an active learning (AL) framework to efficiently create labeled mammography datasets for breast cancer detection. The method significantly reduces the need for expert annotator input, accelerating the development of AI models for early cancer diagnosis.

Keywords:
active learningcancerdeep learningmachine learningmammographysegmentation

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence
  • Machine Learning

Background:

  • Breast cancer is a leading cause of death in women, necessitating effective early detection.
  • Screening programs aim for early detection, but a shortage of labeled image datasets hinders AI model development.
  • Improving AI models for breast cancer detection requires addressing the bottleneck of creating large, accurately labeled datasets.

Purpose of the Study:

  • To present an active learning (AL) framework for segmenting breast masses in 2D digital mammography.
  • To reduce the manual effort required from expert annotators in creating labeled mammographic datasets.
  • To publish a novel dataset of segmented breast masses to facilitate research in AI-driven early detection.

Main Methods:

  • Developed an active learning (AL) framework for pixel-wise binary segmentation of mammographic masses.
  • Created a dataset of 1136 mammographic masses with segmentation labels, validated by radiologists.
  • Simulated a human annotator within the AL framework to train and evaluate AI-assisted labeling methods.

Main Results:

  • Reduced expert annotator input by 44% through the active learning framework.
  • Published a dataset of 1136 binary segmentation labels for mammographic masses.
  • Validated the quality of proposed labels using intersection over union on a public dataset.

Conclusions:

  • Active learning significantly enhances the efficiency and time-effectiveness of creating labeled mammogram datasets.
  • The proposed framework aids in developing high-quality datasets with minimized manual effort.
  • This research supports advancements in digital mammography and AI-based breast cancer screening.