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Relationship Between Leptin and Heart Failure: A Meta-Analysis

Xin Sun1, Caihong Xin2, Jiayi Yao1

  • 1Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou, CN.

Global Heart
|May 26, 2025
PubMed

Insights

Leptin levels are significantly higher in individuals with heart failure (HF) compared to healthy controls. This meta-analysis clarifies the controversial association between leptin and HF, aiding potential diagnostic and therapeutic strategies.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biomarkers

Background:

  • Heart failure (HF) affects over 60 million globally, presenting a significant health challenge.
  • Previous research suggests a link between leptin and HF, but findings are inconsistent.
  • The precise association between leptin levels and heart failure remains controversial.

Purpose of the Study:

  • To systematically review and meta-analyze existing studies on leptin levels in heart failure patients.
  • To clarify the controversial relationship between leptin and heart failure.

Main Methods:

  • A comprehensive literature search was performed across major scientific databases (Web of Science, Wiley, Embase, PubMed).
  • Studies were identified using keywords 'leptin' combined with 'heart failure' and 'HF'.
  • Meta-analysis was conducted, reporting standardized mean differences (SMD) and 95% confidence intervals (CI).

Main Results:

  • Eighteen studies involving 1149 HF patients and 622 healthy controls were included.
  • Leptin levels were found to be significantly elevated in patients with heart failure compared to healthy individuals (SMD, 0.54; 95% CI [0.15, 0.93]).

Conclusions:

  • This systematic review is the first to comprehensively evaluate the relationship between leptin and heart failure.
  • The findings indicate a significant association between higher leptin levels and heart failure.
  • Understanding leptin's role in HF could advance diagnostic and treatment approaches.
Abstract

Keywords:
HFheart failureleptin

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