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Quantitative Solid-State NMR Spectroscopy (qSSNMR) in Pharmaceutical Analysis
Zhaoxi Zheng1, Kang Chen2, Yang Liu3
1Department of Chemistry, Brandeis University, Waltham, Massachusetts, USA.
None:
Pharmaceutical analysis is essential to drug development and quality assurance, ensuring that products meet stringent safety and efficacy standards. Quantitative solid-state NMR (qSSNMR) has become a key technique, enabling precise quantification and characterization of solid drug formulations. This mini-review highlights the evolution of qSSNMR, focusing on improvements in detection limits, resolution, and high-throughput capabilities. This review explores technical advancements and applications for analyzing complex pharmaceutical mixtures. While challenges remain for widespread adoption, efforts in automation, user-friendly software, and collaboration aim to address these.
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