[Neurophysiology of psychiatric disorders: building a national high-density electroencephalography platform]

The PEPR PROPSY EEG-MIND project aims to develop transdiagnostic EEG biomarkers for psychiatric disorders, such as autism, schizophrenia and mood disorders. It combines experimental tasks (rest, mismatch negativity, sensori-motor, audiovisual) to study brain connectivity and neurophysiological abnormalities at the individual level. The aim is to identify markers of oscillatory anomalies, excitation/inhibition ratio, wave propagation and connectivity, and then apply normative models to highlight specific neurocognitive profiles associated to the underlying neurophysiology, which could benefit from personalized targeted approaches such as neuromodulation.