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3D multi-phase balanced non-steady-state free precession acquisition for multi-parameter mapping
Riwaj Byanju1, Gyula Kotek1, Mika W Vogel2
1Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Magma (New York, N.Y.)
|May 26, 2025
Summary
This study introduces a 3D multi-parametric mapping sequence (MP-b-nSSFP) for faster MRI scans. While accurate in phantoms, in vivo T1 mapping showed underestimation compared to reference methods.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Biomedical Engineering
- Medical Physics
Background:
- Multi-parametric mapping provides comprehensive tissue characterization.
- Fast and accurate MRI techniques are crucial for clinical applications.
Purpose of the Study:
- To present and evaluate a novel 3D multi-parametric balanced steady-state free precession (MP-b-nSSFP) sequence.
- To assess the feasibility of achieving clinically acceptable scan times for multi-parametric mapping.
Main Methods:
- Evaluation of 3D MP-b-nSSFP sequence parameters: RF pulse type, readout duration, undersampling, and acceleration factor.
- Utilized subspace-constrained reconstruction and extended spiral readouts for accelerated acquisition.
- Compared repeatability and accuracy of T1 and T2 maps against a reference technique in phantoms and volunteers.
Main Results:
- Non-selective RF pulses demonstrated lower bias compared to selective pulses.
- Phantom T1 and T2 maps agreed well with nominal and reference values.
- In vivo T1 values were underestimated relative to the reference scan.
- Acquisition of high-resolution maps (1x1x3 mm^3) was achieved in 11 minutes.
Conclusions:
- The 3D MP-b-nSSFP sequence enables multi-parametric mapping within clinically relevant scan times.
- Phantom results show good agreement with reference methods, validating the sequence's potential.
- Further investigation is needed to address the underestimation of in vivo T1 values.
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