Animal models for age-related osteoporosis.

Area of Science:

• Bone Biology and Disease
• Gerontology
• Pharmacology and Toxicology

Background:

• Osteoporosis is a prevalent age-related skeletal disorder significantly impacting quality of life in both men and women.
• It arises from an imbalance between osteoblast and osteoclast activity, leading to increased bone degradation, impaired bone mass, and microarchitectural changes.
• Inadequate treatment of osteoporosis imposes a substantial economic burden, highlighting the need for novel therapeutic strategies.

Purpose of the Study:

• To review and discuss animal models utilized in the study of age-related osteoporosis.
• To identify and evaluate the suitability of various animal models for preclinical research in osteoporosis.
• To contribute to the development of new treatment strategies for age-related osteoporosis.

Main Methods:

• This narrative review focuses on existing literature concerning animal models for age-related osteoporosis.
• Key animal models, including mice, fish, and large animals, are discussed.
• The review synthesizes information on the application and limitations of these models in osteoporosis research.

Main Results:

• Various animal models, such as mice, fish, and larger mammals, are employed in osteoporosis research.
• These models offer valuable insights into the pathogenesis of age-related bone loss.
• The selection of an appropriate animal model is critical for the successful investigation of osteoporosis.

Conclusions:

• Animal models are indispensable tools for understanding and treating age-related osteoporosis.
• Further research utilizing these models can facilitate the discovery of novel therapeutic interventions.
• This review aims to guide the selection of appropriate animal models for future osteoporosis research and drug development.