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Related Experiment Video

Updated: Jun 15, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
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Imaging of Adrenal Masses.

Francis T Delaney1, Ryan Chung2, Michael A Blake2

  • 1Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|May 26, 2025
PubMed
Summary
This summary is machine-generated.

Adrenal lesions require careful evaluation to rule out malignancy and hormone excess. Imaging strategies, including CT and MRI, guide management based on lesion characteristics and patient factors.

Keywords:
adrenal glandscomputed tomographymagnetic resonance imagingneoplasmspositron emission tomography

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Area of Science:

  • Radiology
  • Endocrinology
  • Oncology

Background:

  • Adrenal lesions are frequently detected and necessitate appropriate management, particularly when clinically significant.
  • The primary goal in evaluating adrenal lesions is to exclude malignancy and hormone excess due to associated morbidity and mortality.

Purpose of the Study:

  • To review the role of imaging in the evaluation of adrenal lesions.
  • To describe various imaging modalities and strategic approaches for adrenal lesion assessment.
  • To highlight key imaging findings relevant to clinical decision-making.

Main Methods:

  • Noncontrast computed tomography (CT) is the recommended first-line imaging for adrenal lesions.
  • Indeterminate lesions may undergo further characterization with adrenal protocol CT (contrast-enhanced) or magnetic resonance imaging (MRI).
  • Positron emission tomography-computed tomography (PET-CT) can be utilized in specific clinical contexts.

Main Results:

  • Clinical guidelines advocate for dedicated imaging of adrenal incidentalomas unless definitively benign on initial scans.
  • Imaging strategies are tailored based on patient history, detection method, lesion characteristics (size, heterogeneity, lipid content), and hormonal status.
  • Special considerations apply to pregnant patients, individuals under 40, and those with a history of extra-adrenal malignancy.

Conclusions:

  • This review provides a comprehensive overview of imaging's role in managing adrenal lesions.
  • It details available imaging options, investigation pathways, and critical imaging findings.
  • Effective imaging is crucial for accurate diagnosis and management of adrenal lesions.