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Updated: Sep 20, 2025
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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
Published on: February 27, 2018
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S100B in postoperative cognitive impairment: systematic review and meta-analysis
Shuihuan Lu1, Jinning Zhang2, Xueyang He2
1General Practice, The 924th Hospital of Joint Logistics Support Force of the PLA, No.1, Xinqiaoyuan Road, Xiangshan District, Guilin, Guangxi Zhuang Autonomous Region 541002, China.
Summary
Elevated S-100B protein levels 24 hours after non-cardiac surgery may help detect postoperative cognitive dysfunction (POCD). Neuron-specific enolase and MMSE scores did not show significant differences in predicting POCD.
Area of Science:
- Neuroscience
- Biomarkers
- Surgical Outcomes
Background:
- Postoperative cognitive dysfunction (POCD) is a common complication following surgery.
- POCD is widely believed to be associated with the body's inflammatory response.
- Identifying reliable predictors for POCD is crucial for patient management.
Purpose of the Study:
- To investigate the predictive value of S-100B protein and neuron-specific enolase (NSE) serum levels, along with mini-mental state examination (MMSE) scores, for POCD after non-cardiac surgery.
- To assess these markers at different time points: pre-surgery, 24 hours post-surgery, and 7 days post-surgery.
Main Methods:
- A systematic literature review was performed across major scientific databases (PubMed, Web of Science, Scopus, Google Scholar, Embase) up to January 14, 2025.
- Eligible observational studies examining the relationship between POCD incidence and S100B, NSE, and MMSE scores were included.
- Data analysis focused on changes in marker levels and MMSE scores relative to pre-operative baseline.
Main Results:
- Patients who developed POCD exhibited significantly higher S100B levels 24 hours post-surgery compared to their pre-operative levels.
- No significant differences were observed in S100B levels at 7 days, NSE levels at 24 hours or 7 days, or MMSE scores at 24 hours or 7 days between POCD and non-POCD groups.
- In patients aged 60 and above, higher post-operative S100B levels at 24 hours were associated with POCD. Spinal surgery showed significant increases in S100B and NSE, and a decrease in MMSE scores 24 hours post-operatively.
Conclusions:
- S-100B protein shows potential as an early biomarker for detecting POCD following non-cardiac surgery.
- Further research is warranted to fully evaluate the prognostic capabilities of S-100B in POCD.
- NSE and MMSE scores did not demonstrate significant predictive value for POCD in this analysis.
