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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Related Experiment Video

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Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
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Postnatal Cord Blood Sampling: Clinical Report.

David A Kaufman1, Ashley M Lucke2, James J Cummings3

  • 1Department of Pediatrics, Division of Neonatology, University of Virginia School of Medicine, Charlottesville, Virginia.

Pediatrics
|May 26, 2025
PubMed
Summary
This summary is machine-generated.

Postnatal umbilical cord blood sampling (PCBS) offers a safe alternative to neonatal phlebotomy, reducing infant blood loss and pain. This method supports various neonatal tests and may decrease the need for transfusions and intracranial hemorrhage risk.

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Area of Science:

  • Neonatal Medicine
  • Pediatric Hematology
  • Clinical Pathology

Background:

  • Umbilical cord blood after placental separation is of infant origin and suitable for neonatal testing.
  • Neonatal phlebotomy is often indicated for NICU admissions, sepsis evaluations, and congenital anomalies.
  • Traditional neonatal phlebotomy can cause significant blood loss and pain during a critical transition period.

Purpose of the Study:

  • To review the evidence, safety, and methods for postnatal umbilical cord blood sampling (PCBS).
  • To highlight PCBS as an alternative to direct neonatal phlebotomy.
  • To discuss the broad applicability and benefits of PCBS in neonates.

Main Methods:

  • Review of existing literature on postnatal umbilical cord blood sampling.
  • Analysis of indications for neonatal blood sampling.
  • Description of PCBS collection techniques and applications.

Main Results:

  • PCBS avoids neonatal blood loss and phlebotomy pain, especially beneficial for very low birth weight infants.
  • PCBS demonstrated benefits including stable blood pressure, reduced need for vasopressors and transfusions, and potentially lower intracranial hemorrhage risk.
  • PCBS is suitable for term and preterm infants and can be used for a wide range of tests, including complete blood counts, blood cultures, genetic testing, and newborn screening.

Conclusions:

  • Postnatal umbilical cord blood sampling is a safe and effective method for neonatal blood collection.
  • PCBS offers significant advantages over direct neonatal phlebotomy, improving infant outcomes and reducing iatrogenic stress.
  • The versatility of PCBS supports its use in routine testing, research, and cord blood banking, even after delayed cord clamping or cord milking.