Related Experiment Video

Updated: Aug 6, 2026

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without

Jin Wang1, Wei-Feng Yan1, Ke Shi1

  • 1Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Cardiovascular Diabetology
|May 26, 2025
PubMed

Insights

Patients with type 2 diabetes mellitus and obstructive coronary artery disease have impaired right ventricular function. This impairment increases their risk of mortality and heart failure hospitalization.

Area of Science:

  • Cardiology
  • Diabetology
  • Medical Imaging

Background:

  • Obstructive coronary artery disease (OCAD) represents a significant risk factor for patients with type 2 diabetes mellitus (T2DM).
  • Limited data exist on right ventricular (RV) function and clinical outcomes in T2DM patients with or without OCAD.
  • Understanding these differences is crucial for developing targeted prevention and management strategies.

Purpose of the Study:

  • To investigate differences in RV function between T2DM patients with and without OCAD.
  • To compare clinical outcomes in these patient groups.
  • To identify the impact of OCAD on RV myocardial strain and long-term prognosis in T2DM.

Main Methods:

  • 246 T2DM patients (141 without OCAD, 105 with OCAD) and 85 controls were studied.
  • Cardiovascular magnetic resonance imaging assessed RV structure, function, and global myocardial strain.
  • Clinical endpoints (mortality, heart failure hospitalization, composite outcome) were tracked over a median of 5.7 years.

Main Results:

  • RV global circumferential, longitudinal peak strain, and peak systolic strain rate progressively decreased from controls to T2DM(OCAD-) and further to T2DM(OCAD+) patients.
  • OCAD presence correlated with impaired RV global peak strain, circumferential peak strain, longitudinal peak strain, peak systolic strain rate, and peak diastolic radial strain rate in T2DM.
  • T2DM patients with OCAD had a 1.91-fold increased risk of adverse clinical outcomes compared to those without OCAD.

Conclusions:

  • T2DM patients with OCAD exhibit distinct RV functional impairments, including more severe systolic and diastolic dysfunction.
  • These patients face significantly worse long-term clinical outcomes.
  • OCAD is an independent predictor of adverse events in T2DM patients.
Abstract

Keywords:
Cardiac magnetic resonance imagingObstructive coronary artery diseaseType 2 diabetes mellitus

More Related Videos

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft05:25

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...