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Temperature and histamine receptor function--what is really happening?

D A Cook, C A Krueger, A Michalchuk

    Canadian Journal of Physiology and Pharmacology
    |June 1, 1985
    PubMed
    Summary
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    Histamine receptor sensitivity changes significantly at low temperatures, challenging the idea of a simple H1-H2 receptor shift. Research reviews evidence and proposes a new model for histamine responses in smooth muscle.

    Area of Science:

    • Pharmacology
    • Physiology
    • Biochemistry

    Background:

    • Early research indicated a shift from histamine H1 to H2 receptors at temperatures below 20°C.
    • This was based on guinea-pig ileum sensitivity changes to the H2 antagonist metiamide as temperature decreased.
    • Recent studies question a straightforward H1-H2 receptor transition but confirm significant histamine response alterations in smooth muscle at low temperatures.

    Purpose of the Study:

    • To review existing evidence on histamine response modifications in smooth muscle at reduced temperatures.
    • To present new experimental data regarding these temperature-dependent changes.
    • To propose a unifying model explaining the observed histamine receptor alterations.

    Main Methods:

    • Review of published literature on histamine receptor pharmacology at varying temperatures.

    Related Experiment Videos

  • Experimental studies on smooth muscle preparations exposed to histamine at different temperatures.
  • Analysis of receptor binding and functional assays to assess histamine interactions.

    • Main Results:

    • Evidence suggests complex alterations, not a simple H1-H2 receptor transition, in histamine responses at low temperatures.
    • Smooth muscle preparations exhibit significant changes in sensitivity and reactivity to histamine when cooled.
    • New data presented supports a nuanced understanding of temperature's role in histamine signaling.

    Conclusions:

    • The concept of a simple H1-H2 receptor transition at low temperatures is not fully supported by current evidence.
    • Significant modifications in histamine's effects on smooth muscle occur at reduced temperatures.
    • A proposed model integrates diverse observations, offering a more comprehensive explanation for histamine's altered actions.