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Breast Myofibroblastoma: A Single Institutional Case Series.

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Breast myofibroblastoma (BM) is a rare benign tumor. Surgical excision offers favorable outcomes, but distinguishing BM from other spindle cell tumors is crucial for accurate diagnosis and management.

Keywords:
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Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Breast myofibroblastoma (BM) is an uncommon benign mesenchymal tumor.
  • It predominantly affects older males and postmenopausal females.

Purpose of the Study:

  • To analyze the clinicopathologic features of breast myofibroblastoma.
  • To evaluate immunohistochemical profiles and treatment outcomes for BM.

Main Methods:

  • Retrospective review of five BM cases diagnosed between 1998 and 2024.
  • Analysis of clinical, histopathologic, and immunohistochemical data.
  • Assessment of surgical treatment approaches and follow-up outcomes.

Main Results:

  • Median age at diagnosis was 68 years; mean tumor size was 5.06 cm.
  • Histopathology revealed spindle cells with adipose tissue and collagen.
  • Immunohistochemistry showed positivity for desmin and CD34; S100 was negative.

Conclusions:

  • Breast myofibroblastoma is a benign entity with excellent prognosis after surgical excision.
  • Variability in immunohistochemical staining necessitates careful differentiation from other spindle cell tumors.
  • Further case studies and refined diagnostic markers can improve clinical management.