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Updated: Sep 20, 2025
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Desymmetrization strategy in natural product total synthesis
Haichao Liu1, Kai Tang1, Hao Zeng1
1Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, Guangxi, P. R. China. liuhaichao@gxnu.edu.cn.
None:
Desymmetrization strategies have emerged as practical methods for the efficient construction of desired molecules from readily accessible symmetrical precursors. This approach has found widespread application in natural product total synthesis as it simplifies the materials preparation, enables the precise control of chirality formation, and inspires innovative retrosynthetic analysis. Here, we summarize recent advances (2014-2024) of the applications of desymmetrization strategies in natural product total synthesis, and showcase their advantages in designing new reactions and synthetic strategies, with the aim to foster their wider application in total synthesis.
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