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The silent saboteur: oxidative stress and the path to cognitive dysfunction
Tulia Fernanda Meira Garcia1, Janaína Aparecida Favero Desio2, Everton Ferreira de Souza3
1Multicampi School of Medical Sciences, Federal University of Rio Grande do Norte, Caicó, Rio Grande do Norte, Brazil.
Neurodegenerative Disease Management
|May 27, 2025
Summary
Oxidative stress and impaired energy metabolism are key in neurodegenerative diseases like Alzheimer's and Parkinson's. Monitoring these factors may reveal new therapeutic targets for early intervention and improved patient outcomes.
Area of Science:
- Neuroscience
- Biochemistry
- Pathology
Background:
- Oxidative stress (OS) is central to age-related cognitive decline, Alzheimer's disease (AD), and Parkinson's disease (PD).
- Elevated OS biomarkers appear early in neurodegenerative disorders.
- OS and neuroinflammation are interconnected, impacting disease progression.
Purpose of the Study:
- To review the bioenergetic cascade in neurodegeneration.
- To emphasize pathophysiological alterations, mechanisms, and therapeutic targets.
- To explore the link between OS, energy metabolism, and neuroinflammation.
Main Methods:
- Critical narrative review of existing literature.
- Analysis of pathophysiological mechanisms in neurodegeneration.
- Exploration of therapeutic targets related to OS and bioenergetics.
Main Results:
- OS and impaired cellular energy dynamics are early markers and downstream effects of neuroinflammation.
- These processes contribute to symptom severity and reduced treatment efficacy in AD and PD.
- OS-related metabolites are potential indicators for early intervention.
Conclusions:
- Understanding the interplay between OS, energy metabolism, and neuroinflammation is crucial for developing effective AD and PD interventions.
- Monitoring OS metabolites offers a promising strategy for identifying therapeutic targets.
- Early clinical intervention targeting OS may reduce neuroinflammation and improve patient outcomes.
Keywords:
Oxidative stressantioxidant therapycognitive declinemitochondrial dysfunctionneurodegenerationMore Related Videos
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