Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multifunctional 3D-Printed Alginate Emulgel Patches Incorporating Plant Extracts for Potential Burn Wound Applications.

Gels (Basel, Switzerland)·2026
Same author

Variable Range Hopping Transport Probed by DNA Sensing in Vertical Graphene and Nanocrystalline Graphite BioFETs.

Micromachines·2026
Same author

Controlled polymerization of methyl acrylate in the presence of copper MOF (Basolite<sup>®</sup>C300): strategy and characterization.

Scientific reports·2026
Same author

Vertical graphene-based electrochemical sensor for cisplatin detection and molecular recognition.

Talanta·2026
Same author

Influence of Rapid Thermal Annealing (RTA) on the Properties of Indium Oxide Nanostructures.

Nanomaterials (Basel, Switzerland)·2026
Same author

Colored Anodic Titania Thin Layers Involving Various Deep Eutectic Solvent Formulations-Evaluation of Corrosion Behavior.

Materials (Basel, Switzerland)·2026

Related Experiment Video

Updated: Mar 31, 2026

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.7K

Field-Effect Transistor Based on Nanocrystalline Graphite for DNA Immobilization.

Bianca Adiaconita1, Eugen Chiriac1, Tiberiu Burinaru1

  • 1National Institute for Research and Development in Microtechnologies-IMT Bucharest, 126A Erou Iancu, Nicolae, 077190 Voluntari, Ilfov, Romania.

Biomolecules
|May 28, 2025
PubMed
Summary

This study demonstrates nanocrystalline graphite field-effect transistors (FETs) for highly sensitive, label-free DNA nucleobase detection. The technology offers rapid genetic analysis and improved diagnostic tools.

Keywords:
DNA technologiesDirac pointfield-effect transistorgraphene-related materialmobilitynucleobase

More Related Videos

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.9K
Flow-assisted Dielectrophoresis: A Low Cost Method for the Fabrication of High Performance Solution-processable Nanowire Devices
09:14

Flow-assisted Dielectrophoresis: A Low Cost Method for the Fabrication of High Performance Solution-processable Nanowire Devices

Published on: December 7, 2017

8.4K

Related Experiment Videos

Last Updated: Mar 31, 2026

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.7K
Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.9K
Flow-assisted Dielectrophoresis: A Low Cost Method for the Fabrication of High Performance Solution-processable Nanowire Devices
09:14

Flow-assisted Dielectrophoresis: A Low Cost Method for the Fabrication of High Performance Solution-processable Nanowire Devices

Published on: December 7, 2017

8.4K

Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Graphene-based field-effect transistors (FETs) show promise for biosensing applications.
  • Nanocrystalline graphite (NCG) offers unique electronic properties and high surface area.
  • Detecting DNA nucleobases is critical for genetic analysis and diagnostics.

Purpose of the Study:

  • To investigate the use of NCG-based FETs for direct DNA nucleobase detection.
  • To explore the interactions between NCG and DNA nucleobases for biosensing.
  • To develop a sensitive, label-free method for DNA detection and sequence recognition.

Main Methods:

  • Fabrication of FETs utilizing a nanocrystalline graphite (NCG) channel.
  • Adsorption of DNA nucleobases onto the NCG channel.
  • Real-time monitoring of changes in the device's electrical characteristics upon nucleobase binding.
  • Utilizing π-π stacking interactions for biomolecule stabilization.

Main Results:

  • NCG-based FETs effectively detect DNA nucleobases.
  • Direct attachment of nucleobases to NCG induces significant, measurable changes in electrical properties.
  • The method achieves highly sensitive and label-free DNA detection.
  • Demonstrated potential for DNA binding and sequence recognition.

Conclusions:

  • NCG-based FETs provide a sensitive platform for label-free DNA nucleobase detection.
  • The strong π-π stacking interactions are key to efficient biomolecule adsorption and detection.
  • This technology advances rapid genetic analysis and biotechnology, enabling improved diagnostic tools.