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LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo Implantation in Mice
Jumpei Terakawa1,2, Sakura Nakamura1,3, Mana Ohtomo1,3
1Graduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.
Biomolecules
|May 28, 2025
Summary
Leukemia inhibitory factor receptor (LIFR) is essential for embryo implantation in mice. LIFR signaling, along with ERBB2, plays a crucial role in successful pregnancy.
Area of Science:
- Reproductive biology
- Mammalian reproduction
- Molecular endocrinology
Background:
- Embryo implantation is vital for mammalian pregnancy.
- Leukemia inhibitory factor (LIF) receptor-STAT3 signaling is key in mice.
- Distinct expression of LIFR and GP130 suggests varied roles.
Purpose of the Study:
- To investigate the specific role of uterine epithelium LIFR in embryo implantation.
- To compare gene expression changes in Lifr eKO and Gp130 eKO mice.
Main Methods:
- Generation of uterine epithelium-specific Lifr knockout (Lifr eKO) mice.
- Comprehensive endometrial gene expression analysis before implantation.
- Comparison with Gp130 eKO mouse models.
Main Results:
- Lifr eKO mice exhibited complete infertility, similar to Gp130 eKO mice.
- Gene deletion altered expression of 299 genes, with 31 downregulated and 57 upregulated in both models.
- Erbb2 and c-Fos identified as key regulators; ERBB2 inhibition impacted implantation.
Conclusions:
- Uterine epithelium LIFR is indispensable for mouse embryo implantation.
- LIFR-ERBB2 signaling is critical for successful embryo implantation.
- Divergent roles of LIFR and GP130 in uterine epithelium warrant further investigation.
