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Clinical significance of Streptococcus milleri
Abstract:
The clinical features of infection in patients from whom Streptococcus milleri was isolated were analysed in an attempt to determine the clinical significance of this organism. During a four-year period Streptococcus milleri was isolated from 232 hospitalized patients. In 44 patients Streptococcus milleri was isolated in pure culture, in 45 patients together with obligate anaerobes, and in 143 patients together with aerobes with or without anaerobes. The 82 patients in whom isolation of Streptococcus milleri was considered significant had the following infections: bacteremia (8 patients), brain abscess (2), pleural empyema (9), lung abscess (1), maxillary sinusitis (7), intra-abdominal abscess (53), infection of pacemaker (1) and infection of vascular graft (1). The 150 patients in whom isolation of Streptococcus milleri was considered of questionable significance had the following: upper respiratory tract infection (12 patients), lower respiratory tract infection (6), acute cholecystitis (8), soft tissue abscess, cellulitis and surgical wound infections (83), bone and joint infections (14), genital infection (25) and miscellaneous infections (2). The overall incidence of infection with Streptococcus milleri was five cases per 1000 admissions. The study showed that Streptococcus milleri is of clinical significance not only in suppurative infections, as previously reported, but also in acute maxillary sinusitis and infection of implant material.
Insights
Streptococcus milleri is a significant cause of various infections, including suppurative conditions, acute maxillary sinusitis, and implant-related infections. This analysis clarifies its clinical importance in hospitalized patients.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Bacteriology
Background:
- The clinical significance of Streptococcus milleri in patient infections requires further elucidation.
- Previous studies have primarily linked Streptococcus milleri to suppurative infections.
Purpose of the Study:
- To analyze the clinical features of infections associated with Streptococcus milleri.
- To determine the clinical significance of Streptococcus milleri in a hospitalized patient population.
Main Methods:
- Retrospective analysis of 232 hospitalized patients over a four-year period.
- Categorization of Streptococcus milleri isolations based on culture purity (pure, with anaerobes, with aerobes).
- Correlation of Streptococcus milleri isolation with specific infection types and clinical outcomes.
Main Results:
- Streptococcus milleri was isolated from 232 patients, with significant findings in 82 cases including bacteremia, brain abscess, pleural empyema, and intra-abdominal abscess.
- Questionable significance was noted in 150 patients with infections like upper/lower respiratory tract infections, soft tissue abscesses, and bone/joint infections.
- The organism was found to be clinically significant in acute maxillary sinusitis and infections involving pacemaker and vascular graft materials.
Conclusions:
- Streptococcus milleri plays a significant role in various suppurative infections.
- This study highlights the clinical importance of Streptococcus milleri in acute maxillary sinusitis.
- The organism is also implicated in infections of implant materials, expanding its known clinical relevance.