Related Experiment Video
Updated: Jun 12, 2025
07:47
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
1.4K
TMEM138: From Biological Functions to Diseases.
1Hua Li, Department of Gynecology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China. yilulihua@sina.com.
Physiological Research
|May 28, 2025
Summary
Transmembrane Protein 138 (TMEM138) plays roles in cell functions and is implicated in diseases. This review details TMEM138
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Transmembrane Protein 138 (TMEM138) is a transmembrane protein.
- TMEM138 is involved in cell proliferation, differentiation, and apoptosis.
- Altered TMEM138 expression is linked to neurodegenerative diseases and tumors.
Purpose of the Study:
- To provide a comprehensive overview of TMEM138.
- To focus on molecular characteristics, biological functions, and disease roles.
- To serve as a reference for future research and clinical applications.
Main Methods:
- Literature review of TMEM138 research.
- Analysis of TMEM138's molecular properties.
- Examination of TMEM138's role in biological processes and diseases.
Main Results:
- TMEM138 exhibits diverse biological functions.
- TMEM138's abnormal expression is associated with significant pathologies.
- Detailed molecular characteristics and functional roles are presented.
Conclusions:
- TMEM138 is a key protein in cellular processes.
- TMEM138 has potential as a biomarker and therapeutic target.
- Further research is warranted for clinical applications.
Related Concept Videos
01:30General Transcription Factors
5.2K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.2K
02:16Transcription Factors
75.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
75.7K
01:31Translation
14.6K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
Translation Produces the Building Blocks of Life
Proteins are...
14.6K
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.4K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.4K
02:30Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
01:27Post-translational Translocation of Proteins to the RER
5.6K
A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
Targeting proteins to the ER
Hsp40 and Hsp70 chaperone molecules bind the translated proteins in the cytosol to prevent their folding. The chaperone binding helps to keep the signal...
Targeting proteins to the ER
Hsp40 and Hsp70 chaperone molecules bind the translated proteins in the cytosol to prevent their folding. The chaperone binding helps to keep the signal...
5.6K