Development of kindling: whole-brain stimulation in rats
Related Experiment Video
Updated: Oct 14, 2026
10:52
Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
Published on: October 2, 2015
Experimental Neurology
|October 1, 1985
Abstract:
Previous studies have demonstrated that low-intensity electrical stimulation of some specific brain regions in several animal species leads to gradual changes in behavior, culminating in generalized seizures (kindling). We found that repeated whole-brain stimulation in rats with electrical currents of 5 and 3 mA elicited progressive behavioral changes and finally triggered convulsive seizures.
