Sex related differences in acetaminophen toxicity in the mouse
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Updated: Oct 13, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Abstract:
Acetaminophen LD50 was two fold lower in female than male mice, the greater sensitivity of female mice for acetaminophen was also reflected in the serum enzyme levels of glutamic oxaloacetic and pyruvic transaminases (SGOT/SGPT), where the enhancement of both enzymes was higher in female than male mice. We could also observe the L-cysteine protection against the toxic effect of acetaminophen. Our results demonstrate that the lethal action of acetaminophen administrated either P.O. or S.C., is sex related.
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