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Updated: Sep 20, 2025

Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels
Published on: August 10, 2010
The stiffness of extracellular matrix in regulating cellular metabolism
Boyang Zha1, Chunlei Zhang1,2, Congying Wu1,2
1Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Abstract:
Cells interact dynamically with the extracellular matrix (ECM), which provides both structural support and biochemical signals that regulate various cellular processes. Among these, the mechanical properties of the ECM, particularly stiffness, play a crucial role in governing cell differentiation, migration, and survival. Recent studies have highlighted the intricate relationship between ECM stiffness and cellular metabolism, influencing key pathways such as glucose, lipid, and amino acid metabolism. This review explores how ECM stiffness modulates these metabolic processes, emphasizing the underlying mechanotransduction mechanisms. In addition, we discuss emerging techniques that enable the investigation of ECM-mediated force sensing and response, providing new insights into the mechanoregulation of metabolism and its implications in disease and therapy.
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