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Updated: Jan 17, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
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Lactate Activates the HCAR1/β-Arrestin2/PP2A Signaling Axis to Mediate STAT1/2 Dephosphorylation and Drive

Zhitao Han1,2, Qi Jia3, Guangjian Bai4

  • 1School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|September 16, 2025
PubMed
Abstract

Keywords:
HCAR1STAT1/2lactateosteosarcomaβ‐Arrestin 2

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