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Updated: Jun 13, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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The Discovery of C7-Substituted Norbornyl Bisamides as RXFP1 Small Molecule Agonists

Shun Su1, Michael C Myers1, Donna M Bilder1

  • 1Research and Development, Bristol Myers Squibb, Co., P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.

Journal of Medicinal Chemistry
|May 28, 2025
PubMed
Summary

Researchers discovered a new compound, 39, that acts as a potent agonist for the relaxin receptor RXFP1. This compound shows promise for treating cardiovascular conditions like heart failure by mimicking relaxin

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