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PRERETINAL HYPERREFLECTIVE DOTS: A Novel Optical Coherence Tomography Sign Associated With the Development of
Bayram Mhibik1, Federico Bernabei1, Marco Pellegrini2,3,4
1Department of Ophthalmology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
Purpose:
To investigate the association between preretinal hyperreflective dots (PHD) with the occurrence of epiretinal membrane (ERM) after pars plana vitrectomy for rhegmatogenous retinal detachment (RRD).
Methods:
This retrospective study included patients who underwent pars plana vitrectomy for RRD at Ophtalmopôle de Paris. Optical coherence tomography scans were acquired at 1, 3, and 6 months and 1 year postsurgery. Preretinal hyperreflective dots were defined as point-like hyperreflective deposits on the inner retinal surface on the first postoperative optical coherence tomography. The association between PHD and ERM was evaluated using logistic regression and Kaplan-Meier analysis.
Results:
Of 894 patients who underwent vitrectomy for RRD, 417 were included in the analysis. Univariate analysis showed significant associations between ERM occurrence and macula-off RRD ( P = 0.043), number of retinal tears ( P = 0.002), use of cryopexy ( P = 0.012), C 2 F 6 tamponade ( P = 0.045), and presence of PHD on optical coherence tomography ( P < 0.001). On multivariate analysis, presence of PHD ( P < 0.001) and use of cryopexy ( P = 0.013) were significant predictors of ERM. Kaplan-Meier analysis indicated that the cumulative probability of developing an ERM at 6 months was 4% in patients without PHD and 26% in patients with PHD ( P < 0.001).
Conclusion:
Preretinal hyperreflective dots are associated with the occurrence of ERM after vitrectomy for RRD.
