[Association between Moyamoya Disease and Autoimmune Thyroid Disorders]

Area of Science:

• Neurology
• Immunology
• Endocrinology

Background:

• Moyamoya disease (MMD) is a progressive cerebrovascular disorder.
• Recent studies suggest a link between MMD and autoimmune thyroid disorders or antithyroid antibodies.

Purpose of the Study:

• To explore the association between MMD and autoimmune thyroid disorders.
• To investigate the role of antithyroid antibodies in MMD pathophysiology.

Main Methods:

• Literature review of studies investigating MMD and thyroid autoimmunity.
• Analysis of clinical associations and potential pathogenetic mechanisms.

Main Results:

• Elevated antithyroid autoantibodies are frequently found in MMD patients, even without overt thyroid dysfunction.
• Thyroid autoimmunity may be associated with MMD progression and cerebrovascular events.
• Genetic factors like RNF213 variants and immunological factors may play a role.

Conclusions:

• Thyroid autoimmunity is frequently observed in Moyamoya disease patients.
• The underlying mechanisms linking thyroid autoimmunity and MMD require further investigation.
• Understanding these associations is crucial for diagnosis and treatment.