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The Hidden Power of Black Pepper: Exploring Piperine's Role in Cancer

Ezgi Nur Cinar1, Nevin Sanlier2

  • 1Department of Nutrition and Dietetics, School of Health Sciences, Ankara Medipol University, 06050, Altındag, Ankara, Turkey.

Plant Foods for Human Nutrition (Dordrecht, Netherlands)
|May 29, 2025
PubMed

Insights

Piperine, from black pepper, shows potential in preventing and treating cancer by affecting multiple molecular pathways. Further research explores its role in managing various cancer types and metastasis.

Area of Science:

  • Oncology
  • Natural Product Chemistry
  • Molecular Biology

Background:

  • Cancer is a complex disease driven by uncontrolled cell growth and migration.
  • Genetic, environmental, and lifestyle factors contribute to cancer development.
  • Natural compounds offer potential avenues for cancer prevention and treatment.

Purpose of the Study:

  • To review the molecular and cellular mechanisms of piperine's anti-cancer effects.
  • To examine piperine's potential in managing cancer formation and progression.
  • To explore piperine's impact on various cancer types.

Main Methods:

  • Review of existing scientific literature on piperine and cancer.
  • Analysis of studies on human cancer cell lines.
  • Examination of data from advanced animal tumor models.

Main Results:

  • Piperine, a key compound in black pepper, exhibits therapeutic properties.
  • Evidence suggests piperine influences multiple pathways in cancer development and metastasis.
  • Studies indicate potential applications for piperine in cancer prevention and treatment.

Conclusions:

  • Piperine demonstrates multifaceted anti-cancer activities.
  • Its molecular mechanisms warrant further investigation for therapeutic development.
  • Piperine holds promise as a natural agent in comprehensive cancer management.
Keywords:
Piper nigrum LAnticancerBlack pepperNatural therapeutic agentsPiperine

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