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Supporting Medication Adherence in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplant Using the BMT4me
Mariam Kochashvili1, Parishma Guttoo1, Emre Sezgin1,2
1Center for Biobehavioral Health, The Abigail Wexner Research Institute, Nationwide Children's Hospital, 431 South 18th Street, Columbus, OH, 43205, United States, 1 6147228958.
Insights
Mobile health (mHealth) apps like BMT4me show promise for improving medication adherence in pediatric hematopoietic stem cell transplant (HCT) patients. Caregivers found the app user-friendly and valuable for managing complex treatments.
Area of Science:
- Pediatric Oncology
- Mobile Health Interventions
- Hematopoietic Stem Cell Transplantation
Background:
- Children undergoing hematopoietic stem cell transplants (HCTs) face high risks of medication nonadherence due to complex outpatient regimens.
- Mobile health (mHealth) interventions can improve adherence in pediatric populations, but HCT-specific research is limited.
Purpose of the Study:
- To assess the usability of the BMT4me mHealth application.
- The app is designed for real-time, personalized medication management, symptom tracking, and journal keeping for pediatric HCT patients.
Main Methods:
- A mixed-methods approach was used with 14 caregivers of children (aged 2-18) in the acute phase post-HCT.
- Usability was measured using the System Usability Scale, reaction cards, caregiver satisfaction surveys, and semistructured interviews over 100 days.
Main Results:
- The BMT4me app was generally rated as easy to use and acceptable by caregivers.
- Caregivers found the app motivating for medication schedules and useful for tracking, with high recommendation rates.
- Positive feedback focused on medication reminders, symptom tracking, and notes features; suggestions included EMR integration and educational content.
Conclusions:
- The BMT4me app demonstrates promising usability for pediatric HCT patients, supporting complex treatment management.
- Caregiver feedback indicates the app is user-friendly and valuable, suggesting potential for broader implementation.
- These findings support further investigation in larger randomized controlled trials to confirm efficacy.
Background:
Due to multifaceted outpatient regimens, children receiving hematopoietic stem cell transplants (HCTs) are at high risk of medication nonadherence, leading to life-threatening complications. Mobile health (mHealth) interventions have proven effective in improving adherence in various pediatric conditions; however, adherence intervention literature on HCT is limited.
Objective:
This study aimed to assess the usability of a mHealth intervention (BMT4me) designed to serve as a real-time, personalized tool for medication management or adherence, symptom tracking, and journal keeping.
Methods:
Following a mixed methods approach, 14 caregivers (n=11, 79% female; n=10, 71% White) of children aged 2-18 (mean age 8.51, SD 5.18) years in the acute phase (first 100 d) post-HCT were recruited. Caregivers were asked to use the BMT4me app for 100 days or until weaning of the immunosuppressant medications to measure usability. The System Usability Scale (assessing functionality and acceptability), reaction cards (assessing desirability), caregiver satisfaction (assessing satisfaction) with the app, and semistructured interviews (assessing participant experience using the app and feedback regarding features) were conducted at two time points, at enrollment and study completion.
Results:
The mean System Usability Scale score was 86.15 (SD 12.81) at enrollment and 73.13 (SD 16.13) at study completion, with most participants reporting the app easy to use and accepable during both time points. At enrollment, 80% (n=12) of caregivers reported that the app was effective in motivating them to stay on schedule, and 87% (n=13) indicated they would recommend it to others. At study completion, 75% (n=6) of caregivers found the app helpful for tracking their child's medication schedule, and 64% (n=5) would recommend it to others. Caregivers described the app as "accessible," "useful," and "valuable." Qualitative interviews during both time points revealed caregivers' positive reactions to the app, particularly regarding medication reminders, tracking symptoms, and notes features, while also providing suggestions for improvements, such as integrating the BMT4me app with electronic medical records, incorporating educational content, adding fields for recording vital signs, and important phone numbers.
Conclusions:
The BMT4me app demonstrated promising usability as a mHealth intervention among pediatric patients undergoing HCT. Caregivers considered the app user-friendly and valuable, with positive feedback on its features, such as medication reminders and symptom tracking. Despite minor reported issues with app functionality, the overall acceptance of the app suggests its potential to support families in managing complex treatment. The findings from this study will inform the feasibility of testing in larger randomized controlled trials.
