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Progressive age-related decrease in regional cerebral blood flow in healthy subjects.

M Globus, E Melamed

    Israel Journal of Medical Sciences
    |August 1, 1985
    PubMed
    Summary
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    Regional cerebral blood flow (rCBF) declines with age, starting as early as the third decade. This progressive decline in brain blood flow is observed even in healthy individuals, not just the elderly.

    Area of Science:

    • Neurology
    • Physiology
    • Aging Research

    Background:

    • Cerebral blood flow is crucial for brain function.
    • Previous studies suggested age-related decline in brain blood flow, primarily in older populations.

    Purpose of the Study:

    • To investigate the age-related changes in regional cerebral blood flow (rCBF) in healthy adults.
    • To determine if the decline in rCBF begins before old age.

    Main Methods:

    • Measured regional cerebral blood flow (rCBF) using the 133xenon inhalation technique.
    • Included 103 healthy, nonhospitalized subjects, with 44 participants under 30 years old.

    Main Results:

    • Mean brain and hemispheric blood flow, as well as rCBF, decreased with advancing age.

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  • A significant decline in rCBF was observed starting in the third decade of life.

    • Conclusions:

    • The decline in regional cerebral blood flow is a progressive phenomenon.
    • This decline begins earlier than previously thought, evident from the third decade onwards in healthy individuals.