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Related Concept Videos

Thermoregulation01:26

Thermoregulation

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The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
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Homeostatic Imbalances in Body Temperature01:19

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Body Temperature01:25

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The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
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Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Assessing Body Temperature - Temporal Artery01:19

Assessing Body Temperature - Temporal Artery

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Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.  
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Preserved Thermoregulation in Huntington's Disease: Insights from an Observational Case-Control Study.

Lucía Simón-Vicente1, Jéssica Rivadeneyra-Posadas2, María Soto-Célix3

  • 1Faculty of Health Sciences, Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, Madrid, Spain.

Movement Disorders Clinical Practice
|May 30, 2025
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Summary

Thermoregulation in Huntington's disease (HD) patients appears largely intact but declines with age and disease severity. Lower body mass index and more CAG repeats in HD patients correlate with reduced temperature recovery post-exercise.

Keywords:
Huntington's diseasebody mass indexmetabolismskinfold thicknessthermography

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Area of Science:

  • Neuroscience
  • Human Physiology
  • Medical Research

Background:

  • Thermoregulation is vital for preventing hyperthermia during physical activity.
  • Little research has explored thermoregulatory alterations in Huntington's disease (HD).

Purpose of the Study:

  • To compare skin temperature changes post-exercise between HD patients and healthy controls.
  • To assess correlations between thermoregulation, body composition, and HD severity.

Main Methods:

  • Cross-sectional study design.
  • Skin temperature assessed via infrared thermography at 13 anatomical sites.
  • HD severity measured using Total Functional Capacity and Unified HD rating scales.
  • Resting oxygen consumption measured by indirect calorimetry.

Main Results:

  • 14 mild-moderate HD patients and 10 healthy controls included.
  • Similar overall thermoregulation capacity observed between groups.
  • In HD patients, reduced post-exercise temperature recovery correlated inversely with BMI (fat mass), resting oxygen consumption, and CAG repeats.
  • Reduced temperature recovery positively correlated with age and quality of life (mental health).

Conclusions:

  • Thermoregulation is generally intact in mild-moderate HD but may decline with aging and disease progression.
  • Lower BMI and increased CAG repeats are associated with impaired thermoregulation recovery in HD.
  • Further research with larger cohorts is needed to validate findings and implications for well-being.