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Quantitative Autonomic Testing
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Association Between Autonomic Dysfunction and Empty Nose Syndrome.

Cheng-Yu Li1, Ta-Jen Lee1, Yi-Wei Chen1

  • 1Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

International Forum of Allergy & Rhinology
|May 30, 2025
PubMed
Summary
This summary is machine-generated.

Empty nose syndrome (ENS) is linked to autonomic dysfunction, with worse symptoms correlating to greater autonomic issues. Surgical treatment may improve these autonomic symptoms.

Keywords:
autonomic systemcomposite autonomic symptom score 31 (COMPASS 31)empty noseempty nose syndrome six‐item questionnaire (ENS6Q)postoperative outcomesinonasal outcome test‐25 (SNOT‐25)

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Area of Science:

  • Otolaryngology
  • Neurology

Background:

  • Empty nose syndrome (ENS) is a complex condition characterized by paradoxical nasal obstruction.
  • ENS is often associated with significant impacts on quality of life.
  • The underlying pathophysiology of ENS remains incompletely understood, with potential links to autonomic nervous system dysfunction.

Purpose of the Study:

  • To investigate the relationship between empty nose syndrome (ENS) and autonomic dysfunction.
  • To determine if the severity of ENS symptoms correlates with the burden of autonomic symptoms.
  • To explore the potential impact of surgical intervention for ENS on autonomic dysfunction.

Main Methods:

  • This study involved a cohort of patients diagnosed with empty nose syndrome.
  • Autonomic function was assessed using standardized questionnaires and objective measures.
  • Symptom severity for both ENS and autonomic dysfunction was quantified.
  • A subset of patients underwent surgical treatment for ENS, and their autonomic symptoms were reassessed post-operatively.

Main Results:

  • A significant correlation was observed between the severity of empty nose syndrome symptoms and the overall burden of autonomic dysfunction.
  • Patients with more severe ENS reported a higher frequency and intensity of autonomic symptoms.
  • Post-surgical follow-up indicated a potential reduction in autonomic dysfunction symptoms in patients treated for ENS.

Conclusions:

  • Empty nose syndrome is closely associated with autonomic dysfunction.
  • Increased severity of ENS symptoms is directly related to a greater autonomic symptom burden.
  • Surgical treatment for empty nose syndrome may offer therapeutic benefits for co-existing autonomic dysfunction.