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Thyroid indices in panic disorder.

S M Fishman, D V Sheehan, D B Carr

    The Journal of Clinical Psychiatry
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid disease was not found in patients with panic attacks. However, a notable percentage of patients showed undetectable thyroid-stimulating hormone (TSH) levels, though its clinical significance remains unclear.

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    Area of Science:

    • Endocrinology
    • Psychiatry
    • Clinical Medicine

    Background:

    • Panic attacks and phobias are common anxiety disorders.
    • Thyroid dysfunction can sometimes mimic or exacerbate psychiatric symptoms.
    • Previous research suggests a potential link between thyroid function and anxiety disorders.

    Purpose of the Study:

    • To investigate the prevalence of thyroid disease in patients experiencing panic attacks.
    • To assess the impact of antipanic medications on thyroid function tests.

    Main Methods:

    • Eighty-two patients with panic attacks (with or without phobias) were evaluated.
    • Thyroid function was assessed using total thyroxine (T4) and triiodothyronine resin uptake (T3RU) measurements.
    • Thyroid-stimulating hormone (TSH) levels were also measured.

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  • Patients were categorized based on medication status (nonmedicated or treated with alprazolam, phenelzine, or imipramine).
  • Main Results:

    • No patients exhibited abnormal total T4 or T3 resin uptake levels.
    • A higher-than-expected incidence of undetectable TSH levels (22%) was observed across all patient groups.
    • This finding persisted regardless of medication status.

    Conclusions:

    • Thyroid disease is unlikely to be a cause of panic attacks in the studied population.
    • Undetectable TSH levels are common in patients with panic attacks, irrespective of antipanic medication.
    • The clinical relevance of suppressed TSH in this context requires further investigation.