Pre-clinical Murine Models of Bone Sarcomas
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Updated: Oct 9, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
Javier Muñoz-Garcia1,2, Jorge W Vargas-Franco3, Agamemnon E Grigoriadis4
1Nantes Université, CNRS, UMR6286, US2B, Nantes, France.
Abstract:
The present chapter gives a brief overview of the main murine models available for bone sarcoma studies, including genetically engineered mice. Particular attention will be paid to the different procedures to induce bone sarcoma from inoculation of tumor cells or implantation of tumor fragments. The technical aspects of anesthesia and surgical procedures, together with postoperative follow-up will be described and discussed in detail.

