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Updated: Sep 19, 2025
Multimodal Optical Imaging Platform for Studying Cellular Metabolism
Published on: June 6, 2025
Fluorescence and photothermal dual-modal image guided integrated diagnosis and treatment
Wan Sun1, Xue-Feng Wang2, Fan Yang2
1Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, Dezhou University, Dezhou 253023, China; Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.
Abstract:
The early diagnosis and real-time monitoring of cancer are great significance for the establishment of integrated diagnosis and treatment systems. In this study, organic molecules as an all-in-one phototheranostic named FL-DPP2 nanoparticles was developed for monitoring the location and size of tumour and for achieving photo and gene synergistic therapy. The photothermal conversion efficiency (η) of FL-DPP2 nanoparticles reached 29.4 % and the quantum yield of 1O2 production was 38 %. In addition, it can deliver the p53 gene into nucleus rapidly under laser irradiation, which induced synergistic cancer cells apoptosis with effective tumor growth inhibition. This work provided an innovative strategy to design and constructed all-in-one nanoplatforms for clinical phototheranostics to realize dual-modal image guided integrated diagnosis and treatment.
Insights
Researchers developed FL-DPP2 nanoparticles for integrated cancer diagnosis and therapy. These nanoparticles enable real-time tumor monitoring and combined photothermal and gene therapy for effective cancer treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Early cancer diagnosis and real-time monitoring are crucial for integrated treatment systems.
- Developing advanced nanoplatforms is key for effective cancer theranostics.
Purpose of the Study:
- To develop an all-in-one phototheranostic agent, FL-DPP2 nanoparticles, for cancer monitoring and synergistic therapy.
- To evaluate the photothermal properties and gene delivery capabilities of FL-DPP2 nanoparticles.
Main Methods:
- Synthesis and characterization of FL-DPP2 nanoparticles.
- Assessment of photothermal conversion efficiency and singlet oxygen production.
- In vitro evaluation of p53 gene delivery and synergistic therapeutic effects under laser irradiation.
Main Results:
- FL-DPP2 nanoparticles exhibited a photothermal conversion efficiency of 29.4% and a 38% quantum yield for 1O2 production.
- Efficient delivery of p53 gene into cancer cells nucleus under laser irradiation.
- Significant inhibition of tumor growth through synergistic photo- and gene therapy, inducing cancer cell apoptosis.
Conclusions:
- FL-DPP2 nanoparticles represent a novel all-in-one nanoplatform for dual-modal image-guided cancer diagnosis and treatment.
- This strategy offers innovative potential for clinical phototheranostics and integrated cancer care.
