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Updated: Sep 19, 2025

Detection of G Protein-coupled Receptor Expression in Mouse Vagal Afferent Neurons using Multiplex In Situ Hybridization
Published on: September 20, 2021
Gut-brain communication: Functional anatomy of vagal afferents
Hans-Rudolf Berthoud1, Heike Münzberg1, Christopher D Morrison1
1Neurobiology of Nutrition & Metabolism Department, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Abstract:
There is increasing interest in interoceptive mechanisms as a key player in mental health. The vagus nerve is an important pathway of communication between the body and the brain, and recent advances in neurobiological techniques have enabled the identification of function-specific populations of vagal sensory neurons. Here we briefly review this progress, focusing on vagal innervation of the gut and its involvement in ingestive behavior, metabolic regulation, and immune defense. While we have learned much about the organization of the peripheral interface of the sensory vagal system, dissemination of information within the brain is still poorly understood. Yet, a deeper understanding of the brain's integration of vagal input will be necessary for the informed development of neuromodulation therapies for various diseases linked to interoception.
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