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Cucurbitane glycosides from Hemsleya chinensis tubers
Miaomiao Li1, Jun Chi1, Manliang Chen1
1Henan University of Chinese Medicine, Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou 450046, China; Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Zhengzhou 450046, China.
Abstract:
Six previously undescribed cucurbitane glycosides, hemchinosides A-F (1-6), along with eleven ones were isolated from Hemsleya chinensis tubers. Compounds 1-6 were characterized by the presence of one to three glucoses substitutions at C-26, and sometimes one glucose at C-3. The structures were confirmed by comprehensive UV, IR, HR-ESI-MS and NMR analyses, and absolute configurations were determined by a comparison of calculated and experimental ECD after acid-hydrolysis. The anti-inflammatory effects of the isolated compounds were further evaluated on lipopolysaccharides-induced RAW 264.7 cells.
