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A Hydrophilic Lubricating Coating with Dual Functions of Antibacterial Adhesion and Urease-Responsive Bactericidal
Yiran Jia1,2, Hongyu Zhang1
1State Key Laboratory of Tribology in Advanced Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
ACS Applied Materials & Interfaces
|June 2, 2025
Summary
This study introduces a novel ureteral stent coating that prevents bacterial adhesion and actively kills bacteria using a urease-responsive mechanism. This innovative approach enhances stent performance and reduces complications like biofilm formation and antibiotic resistance.
Area of Science:
- Biomaterials Science
- Infectious Diseases
- Urology
Background:
- Ureteral stent implantation commonly leads to bacterial biofilm formation and stone deposition.
- Current antimicrobial coatings have limitations, including potential antibiotic resistance and passive protection.
Purpose of the Study:
- To develop a novel hydrophilic lubricating coating for ureteral stents.
- To achieve synergistic antibacterial adhesion and urease-responsive bactericidal activity.
Main Methods:
- Developed a coating based on urease-catalyzed urea hydrolysis, embedding inactive sulfamethoxazole.
- Investigated microscopic adhesion forces to assess antibacterial adhesion.
- Conducted in vitro and in vivo tests using urease-active bacteria.
Main Results:
- The coating demonstrated excellent antibacterial adhesion properties.
- Remarkable urease-responsive bactericidal performance was observed against urease-active bacteria.
- The design reduced nonspecific release and toxicity.
Conclusions:
- The novel coating effectively enhances antimicrobial efficacy for ureteral stents.
- This approach offers significant potential for improving ureteral stent performance and reducing complications.
- The urease-responsive bactericidal mechanism addresses limitations of conventional antimicrobial strategies.
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