Bioinspired Spatiotemporal-Responsive Nanoparticles Synergistically Regulate Mitochondrial Repair and Inhibit...

Area of Science:

• Biomaterials Science
• Cardiovascular Research
• Nanomedicine

Background:

• Acute myocardial infarction (AMI) presents a major global health challenge with high mortality rates.
• Current treatments for AMI are limited by narrow therapeutic windows, ischemia-reperfusion injury, and poor drug targeting.
• Existing therapies struggle with rapid drug clearance and insufficient targeting efficiency.

Purpose of the Study:

• To develop an innovative multifunctional biomimetic nanotherapeutic system for targeted drug delivery in AMI.
• To overcome the limitations of conventional treatments for acute myocardial infarction.
• To create a stable and efficient nano-system for improved cardiac function recovery.

Main Methods:

• Synthesized a triblock copolymer (PDMC/CHP@S/V) using dopamine methacrylamide (DMA), 2-methacryloyloxyethyl phosphorylcholine (MPC), and methacrylate-functionalized cyclodextrin.
• Anchored cardiac homing peptides onto the nanoparticle surface for precise infarct targeting via host-guest interactions.
• Evaluated the nanotherapeutic system's efficacy through in vitro studies on hypoxic cardiomyocytes and in vivo tests on an AMI mice model.

Main Results:

• The nanotherapeutic system demonstrated significant reduction in reactive oxygen species (ROS) levels and alleviated cardiomyocyte apoptosis in vitro.
• In vivo studies showed marked improvement in cardiac function, reduced myocardial fibrosis, and attenuated ventricular remodeling in AMI mice.
• The biomimetic MPC shell effectively reduced macrophage phagocytosis, prolonging circulation time, while DMA provided antioxidant effects.

Conclusions:

• The developed PDMC/CHP@S/V nanotherapeutic system offers an efficient, stable, and safe strategy for targeted AMI treatment.
• This innovative approach addresses key limitations of conventional therapies, improving therapeutic outcomes for acute myocardial infarction.
• The spatiotemporal collaborative delivery design represents a promising advancement in nanomedicine for cardiovascular diseases.