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Updated: Sep 19, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

224

Exploring heart failure prevalence and dimensions: A comprehensive NT-proBNP study in high-risk primary care patients

Ahmet Celik1, Emrah Yesil1, Unal Kılıç2

  • 1Department of Cardiology, Faculty of Medicine, Mersin University, Mersin, Turkey.

ESC Heart Failure
|June 2, 2025
PubMed

Insights

N-terminal probrain natriuretic peptide (NT-proBNP) screening effectively identifies undiagnosed heart failure (HF) in high-risk primary care patients. This approach is crucial for early intervention, particularly for Stage B (pre-HF) and Stage C HF, with a notable prevalence of HF with preserved ejection fraction (HFpEF).

Area of Science:

  • Cardiology
  • Primary Care Medicine
  • Biomarker Research

Background:

  • Early detection of heart failure (HF) is critical for effective intervention, especially in asymptomatic, high-risk populations.
  • Primary care settings are key for identifying individuals with HF risk factors but no prior diagnosis.

Purpose of the Study:

  • To assess the prevalence of undiagnosed HF in high-risk primary care patients.
  • To evaluate the utility of N-terminal probrain natriuretic peptide (NT-proBNP) screening for HF detection and risk stratification.

Main Methods:

  • Prospective cohort study of 874 participants aged ≥40 years with HF risk factors.
  • Comprehensive cardiac evaluations including NT-proBNP measurement, ECG, echocardiography, and laboratory tests.
  • Classification of participants according to ACC/AHA HF staging.

Main Results:

  • A significant proportion of high-risk individuals presented with undiagnosed HF (Stage B and Stage C).
  • Elevated NT-proBNP levels were prevalent in Stage B (84.8%) and Stage C (100%) patients.
  • Heart failure with preserved ejection fraction (HFpEF) predominated in Stage C patients (92.4%); NT-proBNP correlated with cardiac structural and functional parameters.

Conclusions:

  • High-risk primary care patients frequently have undiagnosed HF, necessitating proactive screening.
  • NT-proBNP screening is a valuable tool for early HF identification and risk stratification, particularly for Stage B HF.
  • The high prevalence of HFpEF underscores the need for tailored management strategies in this population.
Abstract

Keywords:
HFpEFNT‐proBNPStage AStage BStage Cprimary care

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