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Efficient storage system for breath hydrogen.

R D Murray, B Kerzner, W C MacLean

    Journal of Pediatric Gastroenterology and Nutrition
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Critocaps significantly improve breath hydrogen sample reliability compared to traditional twist-lock closures. Storing samples below 5 degrees C maximizes hydrogen retention for up to 7 days.

    Area of Science:

    • Clinical diagnostics
    • Biomedical engineering
    • Analytical chemistry

    Background:

    • Breath hydrogen analysis is crucial for diagnosing gastrointestinal disorders.
    • Current breath hydrogen collection methods using plastic syringes with twist-lock closures exhibit limitations.
    • Gradual hydrogen loss and sample variability compromise diagnostic accuracy.

    Purpose of the Study:

    • To evaluate the efficacy of Critocaps as a superior alternative for breath hydrogen sample storage.
    • To compare hydrogen retention between Critocaps and conventional twist-lock closures.
    • To determine optimal storage conditions for preserving breath hydrogen integrity.

    Main Methods:

    • Hydrogen retention was assessed in two syringe brands using Critocaps versus twist-lock closures.

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  • Storage temperatures included 25°C, 5°C, and -20°C over a 72-hour period.
  • Statistical analysis (ANOVA) was employed to compare closure methods and storage conditions.

    • Main Results:

    • Critocaps demonstrated significantly superior hydrogen retention compared to twist-lock closures (p < 0.001).
    • Maximal reliability was achieved when samples were stored at temperatures below 5°C.
    • Extended storage up to 7 days yielded a mean hydrogen retention of 86% ± 6%.

    Conclusions:

    • Critocaps offer a more reliable method for breath hydrogen sample collection and storage.
    • Refrigerated storage (≤5°C) is recommended to maintain sample integrity.
    • Improved sample stability facilitates more accurate and dependable breath hydrogen testing.