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Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
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Metastasis

Metastasis

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Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

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Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Related Experiment Video

Updated: Jun 14, 2025

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

Published on: April 18, 2025

Cell differentiation-related signaling pathways in hepatocellular carcinoma metastasis.

Ze Xiang¹, Jiarui Li¹, Yunyang Xu¹

¹Zhejiang University School of Medicine, Hangzhou, 310058, China.

|June 2, 2025

Summary

This summary is machine-generated.

Hepatocellular carcinoma (HCC) metastasis is driven by key signaling pathways. Targeting these pathways offers new therapeutic strategies for advanced liver cancer.

Keywords:

Cell differentiation Hepatocellular carcinoma Metastasis Signaling pathways Treatment strategies

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Published on: October 24, 2015

Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

Primary liver cancer, particularly Hepatocellular Carcinoma (HCC), presents a significant global health challenge with high mortality rates.
Poor prognosis in advanced HCC is largely attributed to metastasis, a complex process involving epithelial-mesenchymal transition, angiogenesis, and anoikis resistance.
Dysregulation of critical signaling pathways significantly contributes to HCC cell invasion, migration, and aggressive tumor growth.

Purpose of the Study:

To review the pivotal role of key signaling pathways in Hepatocellular Carcinoma (HCC) metastasis.
To summarize current and emerging therapeutic strategies targeting these dysregulated pathways in HCC.

Main Methods:

Literature review focusing on signaling pathways involved in HCC metastasis.
Analysis of current treatment strategies targeting identified pathways.

Main Results:

Signaling pathways including Hippo-YAP/TAZ, Wnt/β-catenin, Notch, Hedgehog, and JAK/STAT are critically involved in promoting HCC cell proliferation, survival, invasion, and distant migration.
Emerging targeted therapies aimed at these pathways show promise for improved tolerability and efficacy in HCC treatment.

Conclusions:

Understanding the molecular mechanisms of HCC metastasis through key signaling pathways is crucial for developing effective treatments.
Targeted therapies offer a promising avenue for improving outcomes in advanced Hepatocellular Carcinoma by inhibiting critical pro-metastatic pathways.