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Restoring Gut-brain Function by Medicinal Herbs Offering Neuroprotection through Suppressing Inflammatory Pathways: A
Fatemeh Abbaszadeh1, Sajad Fakhri2, Behrang Shiri Varnamkhasti2
1Neurobiology Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Current Neuropharmacology
|June 3, 2025
Summary
Medicinal herbs show promise for neurodegenerative diseases by modulating the gut-brain axis and reducing inflammation. This review explores their potential for neuroprotection and improved therapeutic strategies.
Area of Science:
- Neuroscience
- Pharmacology
- Integrative Medicine
Background:
- Neurodegenerative diseases (NDDs) are increasing, necessitating novel therapeutics with improved efficacy and safety.
- Inflammatory mechanisms are increasingly recognized as key contributors to NDD pathogenesis.
- The gut-brain axis, a bidirectional communication pathway, is a critical target for NDD interventions.
Purpose of the Study:
- To systematically review the role of medicinal herbs in neuroprotection.
- To evaluate the impact of herbs on gut-brain axis function and anti-inflammatory mechanisms in NDDs.
- To explore novel delivery systems and clinical applications of medicinal herbs for NDDs.
Main Methods:
- A systematic and comprehensive literature review adhering to PRISMA guidelines.
- Searches conducted across Scopus, PubMed, and ScienceDirect databases.
- Manual review of reference lists and citations to identify relevant studies.
Main Results:
- Medicinal herbs, rich in natural products, act as multi-targeting agents against NDDs.
- Herbs demonstrate potential in restoring gut-brain function and suppressing inflammatory pathways for neuroprotection.
- Novel delivery systems can overcome pharmacokinetic limitations of herbs in targeting the gut-brain axis.
Conclusions:
- Medicinal herbs offer neuroprotective benefits by modulating gut-brain function.
- Herbal interventions can target inflammatory mediators involved in NDDs.
- Further research into herbal therapies and delivery systems is warranted for NDD management.
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