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S&D Messenger: Exchanging Semantic and Domain Knowledge for Generic Semi-Supervised Medical Image Segmentation.
IEEE Transactions on Medical Imaging
|June 3, 2025
Summary
This study introduces a novel framework for medical image segmentation, addressing challenges in data labeling and domain variation. The Semantic & Domain Knowledge Messenger improves performance across semi-supervised medical image segmentation, unsupervised medical domain adaptation, and semi-supervised medical domain generalization tasks.
Area of Science:
- Medical Imaging
- Computer Vision
- Machine Learning
Background:
- Manual labeling for medical image segmentation is time-consuming.
- Domain variations in datasets create challenges like semi-supervised medical domain generalization (Semi-MDG) and unsupervised medical domain adaptation (UMDA).
- Existing methods struggle to integrate semantic and domain knowledge effectively in semi-supervised settings.
Purpose of the Study:
- Develop a unified framework for semi-supervised medical image segmentation (SSMIS), Semi-MDG, and UMDA.
- Address the challenge of disparate knowledge sources (labeled vs. unlabeled data).
- Enhance the comprehension of both semantic and domain knowledge within a single learning process.
Main Methods:
- Introduced a Semantic & Domain Knowledge Messenger (S&D Messenger).
- Facilitated direct knowledge transfer between labeled and unlabeled datasets.
- Integrated the S&D Messenger into a pseudo-labeling approach.
Main Results:
- Achieved significant performance improvements on ten benchmark datasets.
- Demonstrated substantial gains in SSMIS (+7.5%), UMDA (+5.6%), and Semi-MDG (+1.14%) tasks.
- Outperformed state-of-the-art methods specialized for individual tasks.
Conclusions:
- The S&D Messenger provides a generic and effective solution for medical image segmentation tasks with domain variations.
- Direct knowledge delivery between labeled and unlabeled sets is crucial for mastering diverse semi-supervised scenarios.
- The proposed framework offers a versatile approach to advance medical image analysis.

